Episode 1 | Never Going Back to Normal

Will and Natalie battle for their lives after a car accident. An investigation is launched following the suspicious death of Cornelius Rhodes. Maggie receives life-changing news. Dr. Charles cuts his honeymoon short to tend to a p...

Episode 2 | We're Lost in the Dark

A power outage at Med puts multiple patients at risk and tests the skills of the staff and their enthusiastic med students; Natalie returns following her traumatic brain injury; Ethan and April wonder if a family is in their future.

Episode 3 | In the Valley of the Shadows

Dr. Choi and Dr. Charles have difficult decisions to make as a dying man tries to preserve his life with a controversial scientific method. Dr. Marcel and April clash over how to handle a mysterious patient.

Episode 4 | Infection, Part II

An entire apartment complex is forced into quarantine when cases of the deadly virus turns into an epidemic. P.D. chases a lead that could point to a case of bio-terrorism and Will gets dangerously close to the suspect.

Episode 5 | Got a Friend in Me

Dr. Choi and Dr. Marcel don't see eye to eye over the treatment of a patient's chronic pain. Rumors circulate about Maggie. Dr. Manning works to help a young boy, but she is challenged by his parents, who believe in only using hol...

Episode 6 | It's All in the Family

Dr. Manning's actions with a recent patient lead to serious repercussions. April and Noah disagree over a patient who is injured after a beating. Dr. Charles is visited by a childhood friend with a surprising revelation.

Episode 7 | Who Knows What Tomorrow Brings

Dr. Charles and Dr. Halstead sink their teeth into a bloodthirsty case. Dr. Marcel and Maggie throw a traditional craw-fish boil for the staff. A new relationship blossoms while another is left on rocky ground.

Episode 8 | Too Close to the Sun

Maggie gets unsettling news about a new friend and breaks the law to support him; one of the doctors from the Med family is rushed into emergency surgery after a violent assault; a social media influencer lets his users vote on me...

Episode 9 | I Can't Imagine the Future

April receives unfortunate news that makes her question her future with Ethan. Dr. Charles and Maggie see tough times on the horizon. Natalie's memory from the accident starts to return.

Episode 10 | Guess It Doesn't Matter Anymore

A a former patient of Dr. Halstead's resurfaces. Upon Ethan's return, April deals with telling the truth or keeping her secret. Dr. Charles deals with the death of his wife.

Episode 11 | The Ground Shifts Beneath Us

After a major accident at O'Hare, the E.D. is concerned one of their own is in mortal danger. Will's proposal for a safe injection site goes to the board for consideration. Natalie and Goodwin become concerned for Gwen.

Episode 12 | Leave the Choice to Solomon

The team deals with the aftermath of a school bus crash. Dr. Charles worries Dr. Halstead is putting his medical license in jeopardy. Maggie helps a friend in need.

Episode 13 | Pain Is for the Living

Two brothers in critical condition are rushed into the hospital by their parents, leaving Dr. Choi, April and Dr. Charles to tend to their care and left to piece together what actually transpired. Dr. Manning becomes suspicious of...

Episode 14 | It May Not Be Forever

Dr. Manning and Dr. Marcel disagree over an abusive husband. Dr. Halstead struggles with ethics and his decision to work at the safe injection site. Dr. Charles and Elsa reveal a misdiagnosis that may change a family's life.

Episode 15 | I Will Do No Harm

Dr. Charles and Dr. Manning treat a patient who is fully invested in pretending to be someone other than himself. Noah begins to doubt his abilities as a doctor. Dr. Marcel and Dr. Choi are faced with a tough ethical decision. Dr....

Episode 16 | Who Should Be the Judge

A convicted murderer's escape hits close to home when several members of the team find themselves in danger. Dr. Charles and Dr. Halstead continue to clash over patient treatment plans. Dr. Choi and April discover the truth about ...

Episode 17 | The Ghosts of the Past

Marking the series milestone 100th episode, Dr. Manning and Dr. Charles assist in a complicated case helping a 4-year old who they quickly learn is no stranger to the ED. Dr. Marcel and Dr. Choi tend to a police officer with a mys...

Episode 18 | In the Name of Love

Dr. Charles and Goodwin fear Dr. Halstead is repeating his past mistakes when a patient with early-onset Alzheimer's is brought into the E.D. Maggie and Ben become concerned when one of Ben's students is admitted. Dr. Manning and ...

Episode 19 | Just a River in Egypt

Dr. Charles evaluates a 15-year old who is brought into the E.D. after an apparent fall off an overpass. Will sides with Dr. Asher on a risky treatment plan. Tensions run high between Dr. Choi and Dr. Marcel.

Episode 20 | A Needle in the Heart

Dr. Crockett is visited by two New Orleans detectives who have questions about his past. Dr. Choi puts his life in danger to save a child. Dr. Charles gives fatherly advice to his young daughter.

Episode 21 | Episode #5.21