Episode 1 | Watson

Dr. John Watson resumes his medical career as the head of a clinic dedicated to treating rare disorders six months after the death of his friend and partner, Sherlock Holmes, at the hands of Moriarty.

Episode 2 | Redcoat

A man with a bullet in his brain claims to be a Scottish soldier, hiding dark secrets. Watson investigates while searching for Mary's new lover and helping Ingrid overcome her lying tell.

Episode 3 | Wait for the Punchline

Watson and the fellows treat a comic who collapsed at an open mic night; the team becomes concerned when Watson himself collapses and suffers another traumatic brain injury.

Episode 4 | Patient Question Mark

When Sasha discovers a link between her current patient, and a cadaver she dissected during medical school, the team traces the case to Amish country.

Episode 5 | The Man with the Glowing Chest

Watson risks his career to treat a sickle cell patient with an unorthodox surgery. Meanwhile, Ingrid attempts to get her sister admitted to her spinal project.

Episode 6 | The Camgirl Inquiry

Stephens musters the courage to ask Watson to help him when his camgirl suddenly collapses during a video call; the team must act quickly to locate her before it's too late; Watson grapples with guilt over Sherlock's death.

Episode 7 | Teeth Marks

While Watson and the team help a woman whose memory resets every three minutes, Watson struggles with auditory hallucinations and questions whether someone is behind his current decline; Moriarty plots his next move.

Episode 8 | A Variant of Unknown Significance

Watson runs into an old friend of Sherlock Holmes when her son Angus is admitted to UHOP for temporary paralysis; the fellows help Watson after he grows fond of Angus, pursuing various leads to find a cure to his illness.

Episode 9 | Take a Family History

Ingrid tests her experimental paralysis treatment on her sister Gigi. After she starts exhibiting side effects, the team gets involved. Meanwhile, Mary and John bond following a tragedy.

Episode 10 | The Man with the Alien Hand

The clinic's latest patient, who is under treatment for Alien Hand Syndrome, comes under suspicion of fatally pushing his brother in front of a bus. Watson must determine if he is guilty or innocent.

Episode 11 | The Dark Day Deduction

Watson confronts a past trauma from his days in the military when an Army friend's wife reaches out for help, concerned her husband is having a psychotic break. Meanwhile, Moriarty has one final task for Shinwell.

Episode 12 | My Life's Work Part 1

The team scrambles for answers when both of the Crofts fall badly ill with a mysterious ailment.

Episode 13 | Your Life's Work Part 2

The team must make an awful decision when it seems that only one of the twins can be saved. Meanwhile, Shinwell desperately races to help, and Watson finally confronts Moriarty.